Since hippocampal volume measurement is often used in studying Alzheimer’s disease to assess
disease progression, automatic hippocampus segmentation is an important task in clinical applications.
However, it is a challenging task due to its small size, complex shape, fuzzy boundaries, partial volume
effects, and anatomical variability. In this paper we propose a new segmentation method to segment the
hippocampus from brain MRI images automatically.This proposed method presents a new region-based
signed pressure force function, which can efficiently stop the contours at weak boundary. Experimental
results show that the model can fast and effectively segment the intensity inhomogeneous images.