Volume 2, Issue 3
Effect of Operating Parameters on Yield and Anti-Oxidative Activity of Puerarin in Supercritical Process

Ai-Zheng Chen, Yi Li, Foo-Tim Chau, Tsui-Yan Lau, Jun-Yan Hu, Zheng Zhao & Daniel Kam-Wah Mok

Journal of Fiber Bioengineering & Informatics, 2 (2009), pp. 189-196.

Published online: 2009-02

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  • Abstract

Puerarin particles were prepared in the process of solution-enhanced dispersion by supercritical CO_2 (SEDS), where the dichloromethane was employed as an organic non-solvent to increase the saturation ratio of the initial puerarin solution in ethanol. A 2^3 factorial experiment was designed to investigate and identify the relative significance of the processing parameters on the yield of puerarin. In the range of the parameters studied, the yield increased with an increasing non-solvent/solvent ratio, and decreasing puerarin concentration or flow rate. The anti-oxidative activities of puerarin prepared under different parameters were also investigated, and the results show that there is no significant difference. The results indicate that the SEDS process combined with non-solvent could produce puerarin nanoparticles with a higher yield.

  • Keywords

Puerarin yield anti-oxidative activity supercritical CO_2

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@Article{JFBI-2-189, author = {}, title = {Effect of Operating Parameters on Yield and Anti-Oxidative Activity of Puerarin in Supercritical Process}, journal = {Journal of Fiber Bioengineering and Informatics}, year = {2009}, volume = {2}, number = {3}, pages = {189--196}, abstract = {Puerarin particles were prepared in the process of solution-enhanced dispersion by supercritical CO_2 (SEDS), where the dichloromethane was employed as an organic non-solvent to increase the saturation ratio of the initial puerarin solution in ethanol. A 2^3 factorial experiment was designed to investigate and identify the relative significance of the processing parameters on the yield of puerarin. In the range of the parameters studied, the yield increased with an increasing non-solvent/solvent ratio, and decreasing puerarin concentration or flow rate. The anti-oxidative activities of puerarin prepared under different parameters were also investigated, and the results show that there is no significant difference. The results indicate that the SEDS process combined with non-solvent could produce puerarin nanoparticles with a higher yield.}, issn = {2617-8699}, doi = {https://doi.org/10.3993/jfbi12200909}, url = {http://global-sci.org/intro/article_detail/jfbi/5005.html} }
TY - JOUR T1 - Effect of Operating Parameters on Yield and Anti-Oxidative Activity of Puerarin in Supercritical Process JO - Journal of Fiber Bioengineering and Informatics VL - 3 SP - 189 EP - 196 PY - 2009 DA - 2009/02 SN - 2 DO - http://doi.org/10.3993/jfbi12200909 UR - https://global-sci.org/intro/article_detail/jfbi/5005.html KW - Puerarin KW - yield KW - anti-oxidative activity KW - supercritical CO_2 AB - Puerarin particles were prepared in the process of solution-enhanced dispersion by supercritical CO_2 (SEDS), where the dichloromethane was employed as an organic non-solvent to increase the saturation ratio of the initial puerarin solution in ethanol. A 2^3 factorial experiment was designed to investigate and identify the relative significance of the processing parameters on the yield of puerarin. In the range of the parameters studied, the yield increased with an increasing non-solvent/solvent ratio, and decreasing puerarin concentration or flow rate. The anti-oxidative activities of puerarin prepared under different parameters were also investigated, and the results show that there is no significant difference. The results indicate that the SEDS process combined with non-solvent could produce puerarin nanoparticles with a higher yield.
Ai-Zheng Chen, Yi Li, Foo-Tim Chau, Tsui-Yan Lau, Jun-Yan Hu, Zheng Zhao & Daniel Kam-Wah Mok. (2019). Effect of Operating Parameters on Yield and Anti-Oxidative Activity of Puerarin in Supercritical Process. Journal of Fiber Bioengineering and Informatics. 2 (3). 189-196. doi:10.3993/jfbi12200909
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