Metal-organic frameworks (MOFs) demonstrate great potential in biosensing applications, particularly
in sweat sensing, due to their high specific surface area, adjustable pore sizes, and unique catalytic
properties. This review presents the advancements, fabrication techniques and potential applications
of flexible sweat sensors utilizing MOFs. The background and importance of MOFs in sweat sensing
were introduced, underscoring their capacity to elevate the efficiency and precision of such sensors.
The structural optimisation, ligand choice, and fabrication techniques of MOFs were discussed. Various
synthesis methods were explored, including electrochemical, solvothermal, room-temperature, and
microwave/ultrasound-assisted approaches. The applications of MOF-based sweat sensors in trace
element detection, colourimetric sensing, sports monitoring, and biomedicine were highlighted. MOFs’
high sensitivity, selectivity, and stability in these contexts underscore their potential to enhance sensor
performance. The review concludes by discussing the challenges faced by flexible sweat sensors based on
Metal-Organic Frameworks (MOFs), such as the diversification of detectable substances. It outlines
future directions, particularly towards intelligence and high efficiency. It emphasizes the necessity
of achieving high precision and multifunctionality. This review comprehensively analyses the current
status and future prospects of flexible sweat sensors utilising MOFs, highlighting their significant role in
advancing sweat-sensing technology.