Volume 3, Issue 2
Characterization of Silk Fibroin/Hyaluronic Acid Blend Films Cross-linked with EDC

Shu-Qin Yan, Qiang Zhang, Jian-Nan Wang & Ming-Zhong Li

Journal of Fiber Bioengineering & Informatics, 3 (2010), pp. 62-67.

Published online: 2010-03

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  • Abstract

Silk fibroin (SF) / hyaluronic acid (HA) blend films were prepared using 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as crosslinking agent and N-hydroxysuccinimide (NHS), 2-morpholinoethanesulfonic acid (MES) as assistant agents. The physico-chemical properties of the blend films were examined and analyzed. The FTIR shows that HA interferes with SF to form crystal structures, whereas EDC induces SF to form Silk I. Compared to the uncross-linked blend films, the EDC cross-linked blend films show an obvious increase in elongation at break, and a decrease in tensile strength and Young's modulus. The flexibility of the films improved significantly. L929 cells grew well on SF/HA blend films, demonstrating that the blend films cross-linked with EDC have no significant toxicity.

  • Keywords

Silk fibroin hyaluronic acid films blends crosslinking structure cyotocompatibility

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@Article{JFBI-3-62, author = {}, title = {Characterization of Silk Fibroin/Hyaluronic Acid Blend Films Cross-linked with EDC}, journal = {Journal of Fiber Bioengineering and Informatics}, year = {2010}, volume = {3}, number = {2}, pages = {62--67}, abstract = {Silk fibroin (SF) / hyaluronic acid (HA) blend films were prepared using 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as crosslinking agent and N-hydroxysuccinimide (NHS), 2-morpholinoethanesulfonic acid (MES) as assistant agents. The physico-chemical properties of the blend films were examined and analyzed. The FTIR shows that HA interferes with SF to form crystal structures, whereas EDC induces SF to form Silk I. Compared to the uncross-linked blend films, the EDC cross-linked blend films show an obvious increase in elongation at break, and a decrease in tensile strength and Young's modulus. The flexibility of the films improved significantly. L929 cells grew well on SF/HA blend films, demonstrating that the blend films cross-linked with EDC have no significant toxicity.}, issn = {2617-8699}, doi = {https://doi.org/10.3993/jfbi0920100}, url = {http://global-sci.org/intro/article_detail/jfbi/4947.html} }
TY - JOUR T1 - Characterization of Silk Fibroin/Hyaluronic Acid Blend Films Cross-linked with EDC JO - Journal of Fiber Bioengineering and Informatics VL - 2 SP - 62 EP - 67 PY - 2010 DA - 2010/03 SN - 3 DO - http://doi.org/10.3993/jfbi0920100 UR - https://global-sci.org/intro/article_detail/jfbi/4947.html KW - Silk fibroin KW - hyaluronic acid KW - films KW - blends KW - crosslinking KW - structure KW - cyotocompatibility AB - Silk fibroin (SF) / hyaluronic acid (HA) blend films were prepared using 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as crosslinking agent and N-hydroxysuccinimide (NHS), 2-morpholinoethanesulfonic acid (MES) as assistant agents. The physico-chemical properties of the blend films were examined and analyzed. The FTIR shows that HA interferes with SF to form crystal structures, whereas EDC induces SF to form Silk I. Compared to the uncross-linked blend films, the EDC cross-linked blend films show an obvious increase in elongation at break, and a decrease in tensile strength and Young's modulus. The flexibility of the films improved significantly. L929 cells grew well on SF/HA blend films, demonstrating that the blend films cross-linked with EDC have no significant toxicity.
Shu-Qin Yan, Qiang Zhang, Jian-Nan Wang & Ming-Zhong Li. (2019). Characterization of Silk Fibroin/Hyaluronic Acid Blend Films Cross-linked with EDC. Journal of Fiber Bioengineering and Informatics. 3 (2). 62-67. doi:10.3993/jfbi0920100
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