Volume 7, Issue 3
Development and Properties of Electrospun Collagen-chitosan Nanofibrous Membranes as Skin Wound Healing Materials

Tian Zhou , Xiumei Mo & Jiao Sun

Journal of Fiber Bioengineering & Informatics, 7 (2014), pp. 319-325.

Published online: 2014-07

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  • Abstract

The objective of this study was to develop an original anti-bacterial material for skin wound healing. Collagen-chitosan nanofibrous membranes were fabricated by electrospinning. The morphology, tensile strength and contact angle of the membranes were measured. In addition, cell adhesion and proliferation on the membranes were evaluated. The antimicrobial property against Staphylococcus aureus of the membranes was also determined. The results indicated that the diameter of electrospun collagen-chitosan nanofibrous membranes was 221 ± 105 nm, the tensile strength was 1.53 ± 0.12 Mpa and the contact angle was 42.44 ± 4.03 ° . Besides, the collagen-chitosan nanofibrous membranes promoted cell attachment and proliferation and also inhibited the growth of Staphylococcus aureus. In conclusion, these data suggest that electrospun collagen-chitosan nanofibrous membranes have potential to serve as skin wound healing materials, which might be ascribed to its favorable mechanical strength, excellent cell affinity, as well as good antimicrobial properties against Staphylococcus aureus.

  • Keywords

Collagen Chitosan Nanofibers L929 Cell

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@Article{JFBI-7-319, author = {}, title = {Development and Properties of Electrospun Collagen-chitosan Nanofibrous Membranes as Skin Wound Healing Materials}, journal = {Journal of Fiber Bioengineering and Informatics}, year = {2014}, volume = {7}, number = {3}, pages = {319--325}, abstract = {The objective of this study was to develop an original anti-bacterial material for skin wound healing. Collagen-chitosan nanofibrous membranes were fabricated by electrospinning. The morphology, tensile strength and contact angle of the membranes were measured. In addition, cell adhesion and proliferation on the membranes were evaluated. The antimicrobial property against Staphylococcus aureus of the membranes was also determined. The results indicated that the diameter of electrospun collagen-chitosan nanofibrous membranes was 221 ± 105 nm, the tensile strength was 1.53 ± 0.12 Mpa and the contact angle was 42.44 ± 4.03 ° . Besides, the collagen-chitosan nanofibrous membranes promoted cell attachment and proliferation and also inhibited the growth of Staphylococcus aureus. In conclusion, these data suggest that electrospun collagen-chitosan nanofibrous membranes have potential to serve as skin wound healing materials, which might be ascribed to its favorable mechanical strength, excellent cell affinity, as well as good antimicrobial properties against Staphylococcus aureus.}, issn = {2617-8699}, doi = {https://doi.org/10.3993/jfbi09201402}, url = {http://global-sci.org/intro/article_detail/jfbi/4788.html} }
TY - JOUR T1 - Development and Properties of Electrospun Collagen-chitosan Nanofibrous Membranes as Skin Wound Healing Materials JO - Journal of Fiber Bioengineering and Informatics VL - 3 SP - 319 EP - 325 PY - 2014 DA - 2014/07 SN - 7 DO - http://doi.org/10.3993/jfbi09201402 UR - https://global-sci.org/intro/article_detail/jfbi/4788.html KW - Collagen KW - Chitosan KW - Nanofibers KW - L929 Cell AB - The objective of this study was to develop an original anti-bacterial material for skin wound healing. Collagen-chitosan nanofibrous membranes were fabricated by electrospinning. The morphology, tensile strength and contact angle of the membranes were measured. In addition, cell adhesion and proliferation on the membranes were evaluated. The antimicrobial property against Staphylococcus aureus of the membranes was also determined. The results indicated that the diameter of electrospun collagen-chitosan nanofibrous membranes was 221 ± 105 nm, the tensile strength was 1.53 ± 0.12 Mpa and the contact angle was 42.44 ± 4.03 ° . Besides, the collagen-chitosan nanofibrous membranes promoted cell attachment and proliferation and also inhibited the growth of Staphylococcus aureus. In conclusion, these data suggest that electrospun collagen-chitosan nanofibrous membranes have potential to serve as skin wound healing materials, which might be ascribed to its favorable mechanical strength, excellent cell affinity, as well as good antimicrobial properties against Staphylococcus aureus.
Tian Zhou , Xiumei Mo & Jiao Sun. (2019). Development and Properties of Electrospun Collagen-chitosan Nanofibrous Membranes as Skin Wound Healing Materials. Journal of Fiber Bioengineering and Informatics. 7 (3). 319-325. doi:10.3993/jfbi09201402
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