Volume 7, Issue 4
Fabrication and Characterization of Spongy Porous Silk Fibroin Materials Crosslinked by Genipin

Yiyu Wang, Xinyu Wang, Junhua Zhang & Mingzhong Li

Journal of Fiber Bioengineering & Informatics, 7 (2014), pp. 469-478.

Published online: 2014-07

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  • Abstract

The porous Silk Fibroin (SF) scaffolds crosslinked by Genipin (GP) were prepared by freeze-drying. The different amount of GP were added in different concentrations of SF solutions. Compared to the uncross- linked porous SF scaffolds, the GP crosslinked scaffolds were insoluble and showed uniform pores and porosity. The SF scaffolds, with average pore size 39-167 μm and porosity 49-71%, could be obtained by changing concentrations of fibroin solution, When the concentration of fibroin increased, the pore size diminished. The fourier transform-infrared (FT-IR) results revealed that GP could react with the -NH2 groups on the side chains of SF macromolecules to form inter- and intro-molecular covalent bonds. The FT-IR, X-ray Diffraction (XRD) and Differential Scanning Calorimetry (DSC) results also showed that the crystallinity of SF scaffold crosslinked by GP was increased slightly while the thermal stability was improved. This new fabrication way provided the basis theory for producing scaffolds with reasonable structure.

  • Keywords

Silk Fibroin Porous Materials Genipin

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@Article{JFBI-7-469, author = {}, title = {Fabrication and Characterization of Spongy Porous Silk Fibroin Materials Crosslinked by Genipin}, journal = {Journal of Fiber Bioengineering and Informatics}, year = {2014}, volume = {7}, number = {4}, pages = {469--478}, abstract = {The porous Silk Fibroin (SF) scaffolds crosslinked by Genipin (GP) were prepared by freeze-drying. The different amount of GP were added in different concentrations of SF solutions. Compared to the uncross- linked porous SF scaffolds, the GP crosslinked scaffolds were insoluble and showed uniform pores and porosity. The SF scaffolds, with average pore size 39-167 μm and porosity 49-71%, could be obtained by changing concentrations of fibroin solution, When the concentration of fibroin increased, the pore size diminished. The fourier transform-infrared (FT-IR) results revealed that GP could react with the -NH2 groups on the side chains of SF macromolecules to form inter- and intro-molecular covalent bonds. The FT-IR, X-ray Diffraction (XRD) and Differential Scanning Calorimetry (DSC) results also showed that the crystallinity of SF scaffold crosslinked by GP was increased slightly while the thermal stability was improved. This new fabrication way provided the basis theory for producing scaffolds with reasonable structure.}, issn = {2617-8699}, doi = {https://doi.org/10.3993/jfbi12201401}, url = {http://global-sci.org/intro/article_detail/jfbi/4802.html} }
TY - JOUR T1 - Fabrication and Characterization of Spongy Porous Silk Fibroin Materials Crosslinked by Genipin JO - Journal of Fiber Bioengineering and Informatics VL - 4 SP - 469 EP - 478 PY - 2014 DA - 2014/07 SN - 7 DO - http://doi.org/10.3993/jfbi12201401 UR - https://global-sci.org/intro/article_detail/jfbi/4802.html KW - Silk Fibroin KW - Porous Materials KW - Genipin AB - The porous Silk Fibroin (SF) scaffolds crosslinked by Genipin (GP) were prepared by freeze-drying. The different amount of GP were added in different concentrations of SF solutions. Compared to the uncross- linked porous SF scaffolds, the GP crosslinked scaffolds were insoluble and showed uniform pores and porosity. The SF scaffolds, with average pore size 39-167 μm and porosity 49-71%, could be obtained by changing concentrations of fibroin solution, When the concentration of fibroin increased, the pore size diminished. The fourier transform-infrared (FT-IR) results revealed that GP could react with the -NH2 groups on the side chains of SF macromolecules to form inter- and intro-molecular covalent bonds. The FT-IR, X-ray Diffraction (XRD) and Differential Scanning Calorimetry (DSC) results also showed that the crystallinity of SF scaffold crosslinked by GP was increased slightly while the thermal stability was improved. This new fabrication way provided the basis theory for producing scaffolds with reasonable structure.
Yiyu Wang, Xinyu Wang, Junhua Zhang & Mingzhong Li . (2019). Fabrication and Characterization of Spongy Porous Silk Fibroin Materials Crosslinked by Genipin. Journal of Fiber Bioengineering and Informatics. 7 (4). 469-478. doi:10.3993/jfbi12201401
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