TY - JOUR
T1 - Fabrication and Characterization of Spongy Porous Silk Fibroin Materials Crosslinked by Genipin
AU - Yiyu Wang, Xinyu Wang, Junhua Zhang & Mingzhong Li 
JO - Journal of Fiber Bioengineering and Informatics
VL - 4
SP - 469
EP - 478
PY - 2014
DA - 2014/07
SN - 7
DO - http://doi.org/10.3993/jfbi12201401
UR - https://global-sci.org/intro/article_detail/jfbi/4802.html
KW - Silk Fibroin
KW - Porous Materials
KW - Genipin
AB - The porous Silk Fibroin (SF) scaffolds crosslinked by Genipin (GP) were prepared by freeze-drying. The
different amount of GP were added in different concentrations of SF solutions. Compared to the uncross-
linked porous SF scaffolds, the GP crosslinked scaffolds were insoluble and showed uniform pores and
porosity. The SF scaffolds, with average pore size 39-167 μm and porosity 49-71%, could be obtained
by changing concentrations of fibroin solution, When the concentration of fibroin increased, the pore size
diminished. The fourier transform-infrared (FT-IR) results revealed that GP could react with the -NH2
groups on the side chains of SF macromolecules to form inter- and intro-molecular covalent bonds. The
FT-IR, X-ray Diffraction (XRD) and Differential Scanning Calorimetry (DSC) results also showed that
the crystallinity of SF scaffold crosslinked by GP was increased slightly while the thermal stability was
improved. This new fabrication way provided the basis theory for producing scaffolds with reasonable
structure.