Volume 5, Issue 1
Novel Biodegradable Functional Amino Acid-Based Poly(ester Amide) Biomaterials: Design, Synthesis, Property and Biomedical Applications

C. C. Chu

Journal of Fiber Bioengineering & Informatics, 5 (2012), pp. 1-31.

Published online: 2012-05

Preview Full PDF 465 2311
Export citation
  • Abstract

A new family of biodegradable and functional amino acid-based poly(ester amide)s (AA-PEAs) have been designed and synthesized as a new generation of biodegradable biomaterials for biomedical applications. This paper provides an overview of this new generation of biodegradable biomaterials, their design strategy, synthesis, characterization, unique biological property and eventual biomedical applications. AA-PEAs are synthesized from 3 basic building blocks: amino acids, fatty diols and fatty diacids. Due to the enormous variety of these 3 building blocks, a wide range of AA-PEAs could be tailor-designed for meeting specific clinical needs. These AA-PEAs have been engineered into a variety of physical forms ranging from 3D microporous hydrogels, melt-spun fibers, electrospun fibrous membranes, films and microspheres. All these AA-PEAs have shown 2 unique biological properties: support natural wound healing, and muted inflammatory response.

  • Keywords

Amino Acids Poly(ester amide) Biodegradable Inflammation Synthesis Biomaterials Biomedical Applications Fibrous Membrane Electrospinning Hydrogels Microspheres Fibers

  • AMS Subject Headings

  • Copyright

COPYRIGHT: © Global Science Press

  • Email address
  • BibTex
  • RIS
  • TXT
@Article{JFBI-5-1, author = {}, title = {Novel Biodegradable Functional Amino Acid-Based Poly(ester Amide) Biomaterials: Design, Synthesis, Property and Biomedical Applications}, journal = {Journal of Fiber Bioengineering and Informatics}, year = {2012}, volume = {5}, number = {1}, pages = {1--31}, abstract = {A new family of biodegradable and functional amino acid-based poly(ester amide)s (AA-PEAs) have been designed and synthesized as a new generation of biodegradable biomaterials for biomedical applications. This paper provides an overview of this new generation of biodegradable biomaterials, their design strategy, synthesis, characterization, unique biological property and eventual biomedical applications. AA-PEAs are synthesized from 3 basic building blocks: amino acids, fatty diols and fatty diacids. Due to the enormous variety of these 3 building blocks, a wide range of AA-PEAs could be tailor-designed for meeting specific clinical needs. These AA-PEAs have been engineered into a variety of physical forms ranging from 3D microporous hydrogels, melt-spun fibers, electrospun fibrous membranes, films and microspheres. All these AA-PEAs have shown 2 unique biological properties: support natural wound healing, and muted inflammatory response.}, issn = {2617-8699}, doi = {https://doi.org/10.3993/jfbi03201201}, url = {http://global-sci.org/intro/article_detail/jfbi/4857.html} }
TY - JOUR T1 - Novel Biodegradable Functional Amino Acid-Based Poly(ester Amide) Biomaterials: Design, Synthesis, Property and Biomedical Applications JO - Journal of Fiber Bioengineering and Informatics VL - 1 SP - 1 EP - 31 PY - 2012 DA - 2012/05 SN - 5 DO - http://doi.org/10.3993/jfbi03201201 UR - https://global-sci.org/intro/article_detail/jfbi/4857.html KW - Amino Acids KW - Poly(ester amide) KW - Biodegradable KW - Inflammation KW - Synthesis KW - Biomaterials KW - Biomedical Applications KW - Fibrous Membrane KW - Electrospinning KW - Hydrogels KW - Microspheres KW - Fibers AB - A new family of biodegradable and functional amino acid-based poly(ester amide)s (AA-PEAs) have been designed and synthesized as a new generation of biodegradable biomaterials for biomedical applications. This paper provides an overview of this new generation of biodegradable biomaterials, their design strategy, synthesis, characterization, unique biological property and eventual biomedical applications. AA-PEAs are synthesized from 3 basic building blocks: amino acids, fatty diols and fatty diacids. Due to the enormous variety of these 3 building blocks, a wide range of AA-PEAs could be tailor-designed for meeting specific clinical needs. These AA-PEAs have been engineered into a variety of physical forms ranging from 3D microporous hydrogels, melt-spun fibers, electrospun fibrous membranes, films and microspheres. All these AA-PEAs have shown 2 unique biological properties: support natural wound healing, and muted inflammatory response.
C. C. Chu. (2019). Novel Biodegradable Functional Amino Acid-Based Poly(ester Amide) Biomaterials: Design, Synthesis, Property and Biomedical Applications. Journal of Fiber Bioengineering and Informatics. 5 (1). 1-31. doi:10.3993/jfbi03201201
Copy to clipboard
The citation has been copied to your clipboard