Volume 8, Issue 1
Fabrication, Characterization and Biological Evaluation of PRGD/PDLLA/β-TCP Scaffold for Nerve Regeneration

Zhu Zhang, Xiaopei Wu, Yixia Yin, Zheng Zhao & Shipu Li

Journal of Fiber Bioengineering & Informatics, 8 (2015), pp. 133-142.

Published online: 2015-08

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  • Abstract

A novel nerve repairing material PRGD/PDLLA/β-TCP was synthesized and characterized with Scanning Electron Microscope (SEM), Fourier Transform Infrared (FTIR) spectroscopy, and mass loss ratio. The effects of PDLLA or PRGD/PDLLA/β-TCP on viability and growth of Schwann Cells (SCs) were investigated by MTT assay and SEM. After implantation of different materials, histological assessment was performed. The results showed that, compared with PDLLA, PRGD/PDLLA/β-TCP materials displayed better biocompatibility, degradation property and less inflammatory reaction. Moreover, PRGD/PDLLA/β-TCP materials promoted the adhesion and proliferation of Schwann cells and exhibited better degradation performance than pure PDLLA. These results indicated that PRGD/ PDLLA/β-TCP has a potential application in the fields of nerve regeneration.

  • Keywords

Schwann Cells PRGD ⁄ PDLLA ⁄ β-TCP Composite Implantation Inflammatory Factors Biocompatibility

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COPYRIGHT: © Global Science Press

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@Article{JFBI-8-133, author = {}, title = {Fabrication, Characterization and Biological Evaluation of PRGD/PDLLA/β-TCP Scaffold for Nerve Regeneration}, journal = {Journal of Fiber Bioengineering and Informatics}, year = {2015}, volume = {8}, number = {1}, pages = {133--142}, abstract = {A novel nerve repairing material PRGD/PDLLA/β-TCP was synthesized and characterized with Scanning Electron Microscope (SEM), Fourier Transform Infrared (FTIR) spectroscopy, and mass loss ratio. The effects of PDLLA or PRGD/PDLLA/β-TCP on viability and growth of Schwann Cells (SCs) were investigated by MTT assay and SEM. After implantation of different materials, histological assessment was performed. The results showed that, compared with PDLLA, PRGD/PDLLA/β-TCP materials displayed better biocompatibility, degradation property and less inflammatory reaction. Moreover, PRGD/PDLLA/β-TCP materials promoted the adhesion and proliferation of Schwann cells and exhibited better degradation performance than pure PDLLA. These results indicated that PRGD/ PDLLA/β-TCP has a potential application in the fields of nerve regeneration.}, issn = {2617-8699}, doi = {https://doi.org/10.3993/jfbi03201513}, url = {http://global-sci.org/intro/article_detail/jfbi/4693.html} }
TY - JOUR T1 - Fabrication, Characterization and Biological Evaluation of PRGD/PDLLA/β-TCP Scaffold for Nerve Regeneration JO - Journal of Fiber Bioengineering and Informatics VL - 1 SP - 133 EP - 142 PY - 2015 DA - 2015/08 SN - 8 DO - http://doi.org/10.3993/jfbi03201513 UR - https://global-sci.org/intro/article_detail/jfbi/4693.html KW - Schwann Cells KW - PRGD ⁄ PDLLA ⁄ β-TCP Composite KW - Implantation KW - Inflammatory Factors KW - Biocompatibility AB - A novel nerve repairing material PRGD/PDLLA/β-TCP was synthesized and characterized with Scanning Electron Microscope (SEM), Fourier Transform Infrared (FTIR) spectroscopy, and mass loss ratio. The effects of PDLLA or PRGD/PDLLA/β-TCP on viability and growth of Schwann Cells (SCs) were investigated by MTT assay and SEM. After implantation of different materials, histological assessment was performed. The results showed that, compared with PDLLA, PRGD/PDLLA/β-TCP materials displayed better biocompatibility, degradation property and less inflammatory reaction. Moreover, PRGD/PDLLA/β-TCP materials promoted the adhesion and proliferation of Schwann cells and exhibited better degradation performance than pure PDLLA. These results indicated that PRGD/ PDLLA/β-TCP has a potential application in the fields of nerve regeneration.
Zhu Zhang, Xiaopei Wu, Yixia Yin, Zheng Zhao & Shipu Li. (2019). Fabrication, Characterization and Biological Evaluation of PRGD/PDLLA/β-TCP Scaffold for Nerve Regeneration. Journal of Fiber Bioengineering and Informatics. 8 (1). 133-142. doi:10.3993/jfbi03201513
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