Volume 13, Issue 1
Facile Preparation of Silk Fibroin Scaffold Via Direct Solvent Exchange

Qiu-Sheng Wang, Guo-Cong Han, Shu-Qin Yan, Ren-Chuan YouQiang Zhang

Journal of Fiber Bioengineering & Informatics, 13 (2020), pp. 13-21.

Published online: 2020-04

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  • Abstract

Although silk fibroin (SF) materials have gained extensive attention in tissue engineering due to their good machinability, biocompatibility, biodegradability, the complex processes, unmatched pore structures, and chemical crosslinker still hinder their mass production and clinic use. In this study, we reported a direct green and high-efficiency process to fabricate 3D silk fibroin scaffold by solvent exchange in water. The pore parameters were easily regulated with NaCl as auxiliary porogen. More importantly, without using any crosslinker or organic chemical-induced crystallin, SF scaffolds is mainly constructed with stable silk II crystalline (constituent with β-sheets), which was confirmed by Flourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Additionally, the scaffold in our research keeps good tunability on mechanical properties, which has been demonstrated by the results of mechanical testing and provides a feasible way to optimize physical cues for further applications. Thus, the 3D porous silk scaffold with high efficiency and promising structures broaden the potential as a substitute for biomaterials.

  • Keywords

Silk Fibroin Formic Acid Solvent Exchange Porous Materials

  • AMS Subject Headings

  • Copyright

COPYRIGHT: © Global Science Press

  • Email address

zhangq12041008@163.com (Qiang Zhang)

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@Article{JFBI-13-13, author = {Wang , Qiu-Sheng and Han , Guo-Cong and Yan , Shu-Qin and You , Ren-Chuan and Zhang , Qiang}, title = {Facile Preparation of Silk Fibroin Scaffold Via Direct Solvent Exchange}, journal = {Journal of Fiber Bioengineering and Informatics}, year = {2020}, volume = {13}, number = {1}, pages = {13--21}, abstract = {

Although silk fibroin (SF) materials have gained extensive attention in tissue engineering due to their good machinability, biocompatibility, biodegradability, the complex processes, unmatched pore structures, and chemical crosslinker still hinder their mass production and clinic use. In this study, we reported a direct green and high-efficiency process to fabricate 3D silk fibroin scaffold by solvent exchange in water. The pore parameters were easily regulated with NaCl as auxiliary porogen. More importantly, without using any crosslinker or organic chemical-induced crystallin, SF scaffolds is mainly constructed with stable silk II crystalline (constituent with β-sheets), which was confirmed by Flourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Additionally, the scaffold in our research keeps good tunability on mechanical properties, which has been demonstrated by the results of mechanical testing and provides a feasible way to optimize physical cues for further applications. Thus, the 3D porous silk scaffold with high efficiency and promising structures broaden the potential as a substitute for biomaterials.

}, issn = {2617-8699}, doi = {https://doi.org/10.3993/jfbim00328}, url = {http://global-sci.org/intro/article_detail/jfbi/16243.html} }
TY - JOUR T1 - Facile Preparation of Silk Fibroin Scaffold Via Direct Solvent Exchange AU - Wang , Qiu-Sheng AU - Han , Guo-Cong AU - Yan , Shu-Qin AU - You , Ren-Chuan AU - Zhang , Qiang JO - Journal of Fiber Bioengineering and Informatics VL - 1 SP - 13 EP - 21 PY - 2020 DA - 2020/04 SN - 13 DO - http://doi.org/10.3993/jfbim00328 UR - https://global-sci.org/intro/article_detail/jfbi/16243.html KW - Silk Fibroin KW - Formic Acid KW - Solvent Exchange KW - Porous Materials AB -

Although silk fibroin (SF) materials have gained extensive attention in tissue engineering due to their good machinability, biocompatibility, biodegradability, the complex processes, unmatched pore structures, and chemical crosslinker still hinder their mass production and clinic use. In this study, we reported a direct green and high-efficiency process to fabricate 3D silk fibroin scaffold by solvent exchange in water. The pore parameters were easily regulated with NaCl as auxiliary porogen. More importantly, without using any crosslinker or organic chemical-induced crystallin, SF scaffolds is mainly constructed with stable silk II crystalline (constituent with β-sheets), which was confirmed by Flourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Additionally, the scaffold in our research keeps good tunability on mechanical properties, which has been demonstrated by the results of mechanical testing and provides a feasible way to optimize physical cues for further applications. Thus, the 3D porous silk scaffold with high efficiency and promising structures broaden the potential as a substitute for biomaterials.

Qiu-Sheng Wang , Guo-Cong Han , Shu-Qin Yan, Ren-Chuan You & Qiang Zhang . (2020). Facile Preparation of Silk Fibroin Scaffold Via Direct Solvent Exchange. Journal of Fiber Bioengineering and Informatics. 13 (1). 13-21. doi:10.3993/jfbim00328
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