TY - JOUR
T1 - Influenza Viral Membrane Deformation Due to Refolding of HA-Protein: Two-Dimensional Model and Analysis
AU - Vaidya , Naveen K.
AU - Huang , Huaxiong
JO - Advances in Applied Mathematics and Mechanics
VL - 2
SP - 160
EP - 182
PY - 2010
DA - 2010/02
SN - 2
DO - http://doi.org/10.4208/aamm.09-m0954
UR - https://global-sci.org/intro/article_detail/aamm/8325.html
KW - Hemagglutinin protein, Influenza virus, Membrane deformation, Membrane fusion.
AB - <p style="text-align: justify;">In this paper we study influenza viral membrane deformation related
to the refolding of Hemagglutinin (HA) protein. The focus of the
paper is to understand membrane deformation and budding due to
experimentally observed linear HA-protein clusters, which have not
been mathematically studied before. The viral membrane is modeled as
a two dimensional incompressible lipid bilayer with bending
rigidity. For tensionless membranes, we derive an analytical
solution while for membrane under tension we solve the problem
numerically. Our solution for tensionless membranes shows that the
height of membrane deformation increases monotonically with the
bending moment exerted by HA-proteins and attains its maximum when
the size of the protein cluster reaches a critical value. Our
results also show that the hypothesis of dimple formation proposed
in the literature is valid in the two dimensional setting. Our
comparative study of axisymmetric HA-clusters and linear HA-clusters
reveals that the linear HA-clusters are not favorable to provide a
sufficient energy required to overcome an energy barrier for a
successful fusion, despite their capability to cause membrane
deformation and budding.</p>