TY - JOUR T1 - The Effect of Processing and Rheological Variables on the Morphology of Dermal Electrospun Scaffold JO - Journal of Fiber Bioengineering and Informatics VL - 4 SP - 181 EP - 186 PY - 2010 DA - 2010/03 SN - 3 DO - http://doi.org/10.3993/jfbi03201101 UR - https://global-sci.org/intro/article_detail/jfbi/4967.html KW - Elecrospun processing KW - dermal scaffold KW - structural optimization KW - rheological parameters AB - The human skin is the largest organ which protects the body from disease and physical damage. When the skin has been seriously damaged through disease or burns, the body cannot act fast enough to produce necessary replacement cells. Artificial skin grafts were developed as a way to prevent such consequences. This work is related to the design of advanced dermal scaffolds (non-woven fibrous mats) to provide multifunctional properties. Defined target properties are attained by distributing specified base materials at multiple length scales ranging from several nanometers to millimeters. Tissue scaffolds were developed using the electrospinning process, which creates a non-woven fibrous construction of high permeability and proper mechanical integrity similar to the scale of the extra-cellular matrix of cells.