TY - JOUR
T1 - Electrospun Nanofibers for Tissue Engineering
AU - Xiumei Mo, Dawei Li, Hany A. EI-Hamshary & Salem S. Al-Deyab
JO - Journal of Fiber Bioengineering and Informatics
VL - 3
SP - 225
EP - 235
PY - 2013
DA - 2013/06
SN - 6
DO - http://doi.org/10.3993/jfbi09201301
UR - https://global-sci.org/intro/article_detail/jfbi/4837.html
KW - Nanofiber
KW - Electrospinning
KW - Tissue Engineering
KW - P (LLA-CL)
KW - Scaffolds
AB - Electrospun nanofibers have increasingly attracted attention to be used as new generation tissue
engineering scaffolds since they have the nanofibrous structure, which can biomimic the native
Extracellular Matrix (ECM). This paper gives the review of our 10 years research on electrospun
nanofibers for tissue engineering. Natural polymers like collagen and chitosan have been electrospun into
complex nanofibers to biomimic the native ECM both in structure and components. Collagen-chitosan
or silk fibroin (SF) was also blended with synthetic poly (L-lactide-co-ε-caprolactone) (P(LLA-CL)) and
electrospun into collgen-chitosan-P (LLA-CL) nanofibers or SF-P(LLA-CL) nanofibers to achieve both
good mechanical properties and biocompatibility. Coaxial electrospinning was used to encapsulate the
biomolecules into nanofibers to display antithrombotic properties. The nanofiber scaffolds have been
used for skin, nerve and blood vessel tissue engineering in vivo.