TY - JOUR
T1 - The Characteristics of Self-assembled Tussah Silk Fibroin Nanoparticles for Controlled Drug Release
AU - Jinjing Chen, Hongqin Yu & Jianxin He
JO - Journal of Fiber Bioengineering and Informatics
VL - 2
SP - 189
EP - 197
PY - 2014
DA - 2014/07
SN - 7
DO - http://doi.org/10.3993/jfbi06201406
UR - https://global-sci.org/intro/article_detail/jfbi/4777.html
KW - Tussah Silk Fibroin
KW - Nanoparticle
KW - Drug Release
KW - Self-assembly
AB - Tussah silk fibroin is a promising material for drug release because of protein component, biocompatibility,
aqueous processability, and biodegradability. Tussah silk fibroin nanoparticles were self-assembled and
prepared in this paper. Their appearances and sizes were modified by altering the volume ratios between
tussah silk fibroin and ethanol. When 9 mL of ethanol was added, the average microsphere size was
184.52 nm and the scattered index was 0.2903. The tussah silk fibroin nanoparticles for controlled drug
release was studied and the result showed that the time of drug release was significantly longer. The
process of drug release was divided into rapid release in early stage and slow release in late stage. The
target drug delivery can reduce the negative effects and improve the efficiency of the drug. As a result,
it favors deeper investigation of tussah silk fibroin nanoparticles as drug carriers for controlled release of
sensitive biologicals.