TY - JOUR
T1 - Modified Turning Point Method for Confidence Interval Estimating on Up-and-Down Data. Application in Pharmacodynamic Research
AU - Mei , Wei
AU - Wang , Fengru
AU - Yang , Jerry Zhijian
AU - Chang , Zhu
JO - East Asian Journal on Applied Mathematics
VL - 3
SP - 468
EP - 486
PY - 2021
DA - 2021/05
SN - 11
DO - http://doi.org/10.4208/eajam.280520.220920
UR - https://global-sci.org/intro/article_detail/eajam/19137.html
KW - Up-and-down method, confidence interval, 50% effective dose, modified turning point
method, pharmacodynamic research.
AB - <p style="text-align: justify;">The standard method of dealing with sensitive data is developed by Bliss and
Fisher. The up-and-down method is one of the most important methods in sensitive
experiments. Originated in an explosion experiment in Bruceton, Pennsylvania, in 1940,
it is widely used in military and pharmaceutical research since then. Here we introduce a
modified function based on the Choi turning point estimation [11] and compare it with
three estimations — viz. with Dixon-Mood method, logistic regression, and isotonic
regression. In order to estimate the confidence interval of ED50, we also developed an $R$ package ed50simulation and employed it in pharmacodynamic research.</p>