TY - JOUR
T1 - Influences of Cell-Penetrating Peptide Concentration on the Penetration of Phospholipid Membrane
AU - Wu , Qi
AU - Wu , Kun
AU - Meng , Qing-Tian
JO - Journal of Atomic and Molecular Sciences
VL - 3
SP - 141
EP - 145
PY - 2017
DA - 2017/08
SN - 8
DO - http://doi.org/10.4208/jams.102817.121817a
UR - https://global-sci.org/intro/article_detail/jams/12557.html
KW - 
AB - <p style="text-align: justify;">It is necessary to fully understand the interaction between the cell penetration peptide and the
different types of phospholipid membranes. In this research the interaction between R9 antibacterial
peptide and asymmetric phospholipid is studied by using the method of coarse-grained dynamic simulation.
The investigation shows that when there is only one R9 antibacterial peptide in the system, it is hard to
penetrate through the phospholipid membrane spontaneously. When the concentration of the antibacterial
peptide reaches a certain value, with the help of the enhanced electrostatic interactions and the cooperative
effect, the peptides will pass through the phospholipid bilayer and reach the inside of the cell. Increasing the
concentration of antimicrobial peptides is helpful to improve the penetration rate of the peptides. Our
results can provide some theoretical guidance for drug delivery in the biological system.</p>