@Article{IJNAM-6-455,
author = {Pan , T.-W. and Wang , T.},
title = {Dynamical Simulation of Red Blood Cell Rheology in Microvessels},
journal = {International Journal of Numerical Analysis and Modeling},
year = {2009},
volume = {6},
number = {3},
pages = {455--473},
abstract = {<p style="text-align: justify;">A spring model is applied to simulate the skeleton structure
of the red blood cell (RBC) membrane and to study the red blood cell
(RBC) rheology in microvessels. The biconcave RBC shape in static
plasma and tank-treading behavior of single cell in shear flows have
been successfully captured in this model. The behavior of the RBC in a
Poiseuille flow and the lateral migration of the cells in a shear flow have
been investigated. It is found that the RBCs exhibit parachute shape in
a Poiseuille flow with the curvature closely related to the deformability
of the cell membrane and the hematocrit (Hct) of the blood. With this
spring model, RBCs can recover their initial shapes associated with the
minimal elastic energy when the flow stops. The simulation results also
show that the RBCs migrate to the center of the domain in the radial
direction in a shear flow, which clearly indicates the Fahraeus-Lindqvist
effect in microvessels. The rate of migration toward the center depends
on the shape of the RBC; the biconcave shape enhances this migration.</p>},
issn = {2617-8710},
doi = {https://doi.org/},
url = {http://global-sci.org/intro/article_detail/ijnam/778.html}
}