@Article{JFBI-10-105,
author = {Qing-Yan Peng and Shi-Li Xiao},
title = {Silver-functionalized Polyurethane Composite Nanofibers for Controlled Release and Antibacterial Application},
journal = {Journal of Fiber Bioengineering and Informatics},
year = {2017},
volume = {10},
number = {2},
pages = {105--116},
abstract = {In this study, we report a facile approach to develop composite nanofibrous mat for tissue engineering
application. Montmorillonite (MMT) nanoparticles were first used to load an antipyretic analgesic
drug, aspirin (ASP). The ASP-loaded MMT nanohybrids were mixed with polyurethane (PU) for
subsequent electrospinning to form drug-loaded PU ⁄ MMT ⁄ ASP composite nanofibrous mats. Then
electrospun PU ⁄ MMT ⁄ ASP nanofibers were assembled with a bilayer of polyacrylic acid (PAA) and
poly(ethylene imine) (PEI) through electrostatic interaction. Silver nanoparticles have been immobilized
onto nanofibrous mats by in situ complexation and chemical reduction of AgNO_3 solution to form
PU ⁄ MMT ⁄ ASP ⁄ Ag nanofibrous mats. The PU ⁄ MMT ⁄ ASP ⁄ Ag composite nanofibrous mats were
systematically characterized using scanning electron microscopy (SEM), Fourier transform infrared
spectroscopy, and mechanical testing. In vitro drug release showed that this composite nanofibrous
drug delivery system can effectively mitigate the burst release of the drug and the introduction of MMT
can improve the tensile stress property. Further the antibacterial properties and cytotoxicity evaluation
of these mats demonstrate that the PU ⁄ MMT ⁄ ASP ⁄ Ag has a reasonable activity toward the growth
inhibition of model bacterium Staphylococcus aureus, and the PU ⁄ MMT ⁄ ASP ⁄ Ag nanofibers display
good cytocompatibility. In view of its sustained release profile and excellent biocompatibility, this
double-loaded drug delivery system may have great prospect in tissue engineering.},
issn = {2617-8699},
doi = {https://doi.org/10.3993/jfbim00266},
url = {http://global-sci.org/intro/article_detail/jfbi/10615.html}
}