Volume 5, Issue 3
Study on Prescription Technology of Sofosbuvir/Ledipasvir Tablet

Shihai Gu & Chunyuan Hou

Commun. Comput. Chem., 5 (2017), pp. 86-95.

Published online: 2018-10

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  • Abstract

Clone the Harvoni$^{\rm TM}$(Sofosbuvir/Ledipasvir) tablet manufactured by Gilead Sciences, Inc. and screen out the best formula of prescription, to make the pesticide effect of prepared tablet was equal to the original tablet. Methods: Based on the prescription of HarvoniTM manufactured by Gilead Sciences, Inc., the compatibility test of the excipient with the active ingredient was carried out. The stability of self-made samples and reference preparations were investigated, which includes high temperature, high humidity and light conditions. According to the above test, the most reasonable prescription process was chosen. Results: The determined prescription process contained sofosbuvir (400mg), ledipasvir (90mg), copovidone (97.5mg), croscarmellose sodium (50mg), microcrystalline cellulose (115mg), lactose monohydrate (230mg), magnesium stearate (7.5mg), gum arabic(10mg), opadry film coating powder, and purified water. Conclusion: The determined prescription process was stable and the pesticide effect of prepared tablet was equal to the original tablet, so the prescription design was reasonable.

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@Article{CiCC-5-86, author = {Gu , Shihai and Hou , Chunyuan}, title = {Study on Prescription Technology of Sofosbuvir/Ledipasvir Tablet}, journal = {Communications in Computational Chemistry}, year = {2018}, volume = {5}, number = {3}, pages = {86--95}, abstract = {

Clone the Harvoni$^{\rm TM}$(Sofosbuvir/Ledipasvir) tablet manufactured by Gilead Sciences, Inc. and screen out the best formula of prescription, to make the pesticide effect of prepared tablet was equal to the original tablet. Methods: Based on the prescription of HarvoniTM manufactured by Gilead Sciences, Inc., the compatibility test of the excipient with the active ingredient was carried out. The stability of self-made samples and reference preparations were investigated, which includes high temperature, high humidity and light conditions. According to the above test, the most reasonable prescription process was chosen. Results: The determined prescription process contained sofosbuvir (400mg), ledipasvir (90mg), copovidone (97.5mg), croscarmellose sodium (50mg), microcrystalline cellulose (115mg), lactose monohydrate (230mg), magnesium stearate (7.5mg), gum arabic(10mg), opadry film coating powder, and purified water. Conclusion: The determined prescription process was stable and the pesticide effect of prepared tablet was equal to the original tablet, so the prescription design was reasonable.

}, issn = {2617-8575}, doi = {https://doi.org/10.4208/cicc.2017.v5.n3.4 }, url = {http://global-sci.org/intro/article_detail/cicc/12747.html} }
TY - JOUR T1 - Study on Prescription Technology of Sofosbuvir/Ledipasvir Tablet AU - Gu , Shihai AU - Hou , Chunyuan JO - Communications in Computational Chemistry VL - 3 SP - 86 EP - 95 PY - 2018 DA - 2018/10 SN - 5 DO - http://doi.org/10.4208/cicc.2017.v5.n3.4 UR - https://global-sci.org/intro/article_detail/cicc/12747.html KW - Harvoni$^{\rm TM}$, Prescription Technology, Sofosbuvir. AB -

Clone the Harvoni$^{\rm TM}$(Sofosbuvir/Ledipasvir) tablet manufactured by Gilead Sciences, Inc. and screen out the best formula of prescription, to make the pesticide effect of prepared tablet was equal to the original tablet. Methods: Based on the prescription of HarvoniTM manufactured by Gilead Sciences, Inc., the compatibility test of the excipient with the active ingredient was carried out. The stability of self-made samples and reference preparations were investigated, which includes high temperature, high humidity and light conditions. According to the above test, the most reasonable prescription process was chosen. Results: The determined prescription process contained sofosbuvir (400mg), ledipasvir (90mg), copovidone (97.5mg), croscarmellose sodium (50mg), microcrystalline cellulose (115mg), lactose monohydrate (230mg), magnesium stearate (7.5mg), gum arabic(10mg), opadry film coating powder, and purified water. Conclusion: The determined prescription process was stable and the pesticide effect of prepared tablet was equal to the original tablet, so the prescription design was reasonable.

Shihai Gu & Chunyuan Hou. (2019). Study on Prescription Technology of Sofosbuvir/Ledipasvir Tablet. Communications in Computational Chemistry. 5 (3). 86-95. doi:10.4208/cicc.2017.v5.n3.4
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